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Sandhu, H. S.
- P53 and It’s Applications in Cancer Therapy
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Authors
Affiliations
1 Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Rasalpura - 453446, Mhow, Madhya Pradesh, IN
2 Department of Pharmacology and Toxicology, GADVASU, Ludhiana - 141012, Punjab, IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Rasalpura - 453446, Mhow, Madhya Pradesh, IN
2 Department of Pharmacology and Toxicology, GADVASU, Ludhiana - 141012, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 2 (2015), Pagination: 9-18Abstract
P53 is a tumour suppressor protein encoded by the TP53 gene, which is one of the most commonly mutated gene in human and animal cancers. Missense Mutation of the p53 gene is the most prevalent genetic abnormalities which gives rise to full length p53 containing single amino acid substitution within the sequence-specific DNA binding domain (|Greenblatt et al., 1994)14. p53 plays anti-cancer role, through several mechanisms namely by activating DNA repair, initiating apoptosis and inducing growth arrest. By managing the DNA damage, p53 gene plays an important role in maintaining integrity and stability of the genome and therefore, it has been described as "the guardian of the genome". Restoring p53 function is a major step in the treatment of many cancers by following different strategies like, gene replacement therapy using wild-type p53, reactivation of p53 function, inhibition of p53-Mdm2 interaction etc. Advexin is an Adeno-p53 vector, recognized as an orphan drug by USA, Food and Drug administration in 2003, provides delivery of wild-type p53 to cancer cells and demonstrates anticancer activity following adequate expression of p53 (Nemunaitis and Nemunaitis, 2008)27. Similarly, MI-319 restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals (Mohammad et al., 2009)25. These strategies of p53-based cancer therapy differ greatly between themselves both in the mode of action and the degree of success seen in experimental models. Cancer therapy based around p53 proves to be more efficacious, especially in terms of specificity. But the innovation of successful p53-based cancer therapies is only limited by our understanding of p53 biology and the creative use of such knowledge. In future, p53-based cancer therapy can be a valuable option for the treatment of a variety of tumours in human as well as animals.Keywords
P53/Cancer Therapy.
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- Clinicopathological Studies on Vitamin D3 Toxicity and Therapeutic Evaluation of Aloe vera in Rats
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Authors
Sambhaji G. Chavhan
1,
R. S. Brar
1,
H. S. Banga
1,
H. S. Sandhu
2,
S. Sodhi
1,
P. D. Gadhave
1,
V. R. Kothule
1
Affiliations
1 Departments of Veterinary Pathology, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Departments of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana - 141 004, Punjab, IN
1 Departments of Veterinary Pathology, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Departments of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana - 141 004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 18, No 1 (2011), Pagination: 35-43Abstract
A study was conducted to examine the clinical signs, hematological, biochemical and histopathological changes in vitamin D3 toxicity at a dose rate 2 mg/kg b.wt. of vitamin D3 and to assess the protective effect of Aloe vera in vitamin D3 toxicity. The clinical signs observed were anorexia, progressive weight loss, difficulty in movement and respiration, diarrhea, epistaxis, subnormal body temperature and nervous signs before death. Mortality was observed in treated rats between day 10 and day 19 of treatment. The gross postmortem changes observed were severe emaciation, white chalky deposits on epicardial surface of heart, pin point white deposits on cortical surface of kidneys with pale yellow discoloration and diffused white deposits on serosal surface of stomach and intestine with bloody ingesta in lumen. The hematological changes included non-significant increase in hemoglobin and total leukocyte count and significant increase in relative neutrophil count. The biochemical changes observed were significant increase in plasma concentration of calcium, phosphorus and blood urea nitrogen, whereas a significant decrease in the concentration of albumin and total plasma protein was observed. The histopathological lesions included calcification of various organs, viz., tongue, stomach, intestines, kidney, heart, aorta, larynx, trachea, lungs, spleen, choroid plexus arteries of brain and vas deferens. The Aloe vera juice (2.5% in drinking water) has no protective effect on vitamin D3 toxicity (2 mg/kg b.wt.).Keywords
Aloe vera, calcification, histopathological lesions, hypercalcemia, vitamin D3 toxicity- A Case of Intranasal Hemangioma and Concurrent Tetracycline-induced Ulcerative Gastritis in Dogs
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Authors
Affiliations
1 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab
3 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
1 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
2 Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab
3 Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141 004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 1 (2010), Pagination: 33-36Abstract
Incidence of drug-induced gastritis and ulceration in human medicine is well established. Besides, unilateral hemangioma, a unique concurrent case of tetracycline induced gastric toxicity in a dog, characterized by gastritis and ulceration is being reported here. Grossly, the appearance of gastric ulcers mimicked the appearance of Italian pizza. Histological examination further supported drug-induced etiology in this case. This is probably the one of the few cases in the annals of veterinary medicine to be documented as drug-induced gastric toxicity in dog.Keywords
Dogs, doxycycline, gastritis, histopathology, tetracyclines- Neuropathological Studies of Chickens Following Exposure to Chlorpyrifos
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Authors
Affiliations
1 Departments of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
2 Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
1 Departments of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
2 Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 2 (2010), Pagination: 78-81Abstract
The objective of this study was to determine the putative neuropathological effects in young chickens after administration of a single dose of 55 mg/kg bw chlorpyrifos. The gross lesions of the nervous system comprised of congestions in the brain. Microscopic examination of brain showed mild congestion of cerebral blood vessels and mild perivascular cuffing of lymphomononuclear cells in the cerebral cortex and necrosis of the neurons. The interesting findings were the presence of cytoplasmic vacuolations of cerebral neurons and swelling of the endothelial cell of the cerebral capillaries. Cerebellum showed congestion and hemorrhages in the granular layer and necrosis of Purkinje cell. Sciatic nerve exhibited mild edema, swelling and degeneration of axons, and swelling of Schwann cells. There was a significant inhibition of plasma cholinesterase enzyme activity in chickens administered with chlorpyrifos compared to chickens of control group. The study revealed that administration of chlorpyrifos produces neuropathological lesions in chickens shortly after exposure.Keywords
Chickens, chlorpyrifos, neuropathological effects- Toxic Impacts of Cypermethrin on Behavior and Histology of Certain Tissues of Albino Rats
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Authors
Affiliations
1 Department of Zoology, S.G.N. Khalsa College, Sri Ganganagar, Rajasthan, IN
2 Departments of Veterinary Pathology, GADVASU, Ludhiana, IN
3 Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana, IN
1 Department of Zoology, S.G.N. Khalsa College, Sri Ganganagar, Rajasthan, IN
2 Departments of Veterinary Pathology, GADVASU, Ludhiana, IN
3 Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana, IN